GLP-1-type treatments, such as semaglutide and tirzepatide, can slow digestive transit in some people. Constipation may therefore occur particularly at the start or after a dose increase.
Why does it happen?
Reduced appetite can lower the amount of food, fibre and fluids consumed. Medicines can also alter digestive timing. If you eat much less, drink little water and move less, constipation becomes more likely.
For safety context, also see the article on Wegovy side effects and the guide to tirzepatide.
What can you try if your doctor allows it?
- gradually increasing fibre: vegetables, pulses, oats and seeds;
- regular hydration throughout the day;
- walking after meals and gentle physical activity;
- small meals that still include protein and fibre;
- medical advice before laxatives, especially if you have digestive conditions.
A Mediterranean-style diet is useful because it provides fibre and unsaturated fats, but portions need to be adjusted to tolerability.
Warning signs
Contact your doctor if you develop intense abdominal pain, persistent vomiting, severe bloating, blood in the stool, inability to pass gas or constipation that worsens rapidly. Do not increase the dose or combine treatments without advice.
How can you prevent recurrence?
During an online nutrition consultation, the plan can be adjusted for fibre, protein, fluids and meals you tolerate. Constipation should not be treated as mere discomfort, because it can reduce adherence to treatment.
